Final height after gonadotropin-releasing hormone agonists with or without growth hormone in Korean girls with central precocious puberty and early puberty
نویسندگان
چکیده
Results The mean age at the start of treatment was 8.11 ± 0.70 years in group 1, 8.98 ± 0.38 years in group 2 and 9.46 ± 0.46 years in group 3, respectively. The mean predicted adult height (PAH) SDS at the start of treatment was -1.29 ± 1.16 in group 1, -1.14 ± 0.88 in group 2 and -1.87 ± 1.09 in group 3, respectively. Rate of growth during treatment with GnRHa combined with GH was higher significantly in group 3 (6.89 ± 1.45 cm) than in group 1 (5.27 ± 0.89 cm, p = 0.001) and in group 2 (5.64 ± 0.72 cm, p = 0.022). The mean FH SDS was -0.60 ± 0.88 in group 1, -0.40 ± 1.03 in group 2 and -0.92 ± 0.72, respectively and significantly higher than initial height prediction. For the girls received GnRHa alone, FH SDS was correlated significantly with TH SDS, PAH at the start of treatment, PAH at the discontinuation of treatment. Conclusion After GnRHa treatment in girls with CPP or EP, FH is significantly higher than initial height prediction. GnRHa treatment combined with GH resulted in higher growth rate.
منابع مشابه
Whether all patients with Central precocious puberty should be treated?
Extended Abstract Precocious puberty is the appearance of secondary sexual characteristics before 8 years old in girls and 9 years old in boys. Precocious puberty is divided into 3 groups of central, peripheral and normal variants. Central precocious puberty is accompanied by activation of hypothalamic-pituitary-gonadal axis which causes increase in secretion of GnRH, and in turn increase i...
متن کاملAge of menarche and near adult height after long-term gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty
PURPOSE Gonadotropin-releasing hormone agonist (GnRHa) is known for improving final adult height in patients with central precocious puberty (CPP). This study aimed to investigate the age of menarche and near adult height in girls with CPP who had been treated with GnRHa. METHODS In this retrospective study, we reviewed the medical records of 71 Korean girls with CPP who had started menarche ...
متن کاملGonadotropin Releasing Hormone Agonist Treatment to Increase Final Stature in Children With Precocious Puberty
In the setting of central precocious puberty (CPP), the motivation for hormonal intervention is to help the child to reach a taller adult stature than she would achieve otherwise. While gonadotropin-releasing hormone analogs (GnRHa) constitute an established treatment for improving adult stature in girls presenting with CPP up to age 6 (true precocious puberty), it is not yet clear whether or n...
متن کاملAge at menarche and near final height after treatment with gonadotropin-releasing hormone agonist alone or combined with growth hormone in Korean girls with central precocious puberty
The use of a GnRH agonist (GnRHa) in central precocious puberty (CPP) is known to slow puberty progression, subsequently prevent early menarche, and attenuate the height loss caused by advanced skeletal maturation. But enhancing the final height has been so controversial that an additional approach has been used. We investigated the menarcheal age and near final height (NFH) in girls with CPP t...
متن کاملThe influence of gonadotropin-releasing hormone agonists on anthropometric change in girls with central precocious puberty
Purpose The potential effect of gonadotropin-releasing hormone agonist (GnRHa) treatment on the weight of girls with central precocious puberty (CPP) remains a controversy. We investigated anthropometric changes during and after GnRHa treatment among girls with CPP. Methods This retrospective study evaluated data from 127 girls with CPP who received GnRHa treatment for ≥2 years. Height, weigh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015